| # | Building | City | Floors | Height | Year | |
|---|---|---|---|---|---|---|
| 1 | Seneca One Tower | Buffalo | 38 | 529 ft | 1974 | |
| 2 | Rand Building | Buffalo | 29 | 391 ft | 1929 | |
| 3 | Buffalo City Hall | Buffalo | 32 | 378 ft | 1931 | |
| 4 | Main Place Tower | Buffalo | 26 | 350 ft | 1969 | |
| 5 | Liberty Building | Buffalo | 23 | 345 ft | 1925 | |
| 6 | One M&T Plaza | Buffalo | 21 | 317 ft | 1966 | |
| 7 | Electric Tower | Buffalo | 14 | 294 ft | 1912 | |
| 8 | Buffalo Central Terminal | Buffalo | 20 | 271 ft | 1929 | |
| 9 | Erie County Hall | Buffalo | 4 | 270 ft | 1876 | |
| 10 | 10 Lafayette Square | Buffalo | 20 | 263 ft | 1959 | |
| 11 | Verizon/AT&T | Buffalo | 16 | 258 ft | 1913 | |
| 12 | Robert H. Jackson United States Courthouse | Buffalo | 10 | 255 ft | 2011 | |
| 13 | Main Seneca Building | Buffalo | 17 | 250 ft | 1915 | |
| 14 | Old Post Office | Buffalo | 5 | 244 ft | 1901 | |
| 15 | Edward A. Rath County Office Building | Buffalo | 16 | 223 ft | 1969 | |
| 16 | Kaleida Health Gates Vascular Institute | Buffalo | 10 | 190 ft | 2011 | |
| 17 | Main Court Building | Buffalo | 13 | 188 ft | 1964 | |
| 18 | Roswell Park Clinical Sciences Center | Buffalo | 11 | 182 ft | 2015 | |
| 19 | Buffalo VA Medical Center | Buffalo | 14 | 177 ft | 1950 | |
| 20 | 250 Delaware Avenue | Buffalo | 12 | 174 ft | 2015 | |