| # | Building | Images | Height | Floors | Building type | Year | Status |
|---|---|---|---|---|---|---|---|
| 1 | Hochhaus am Graf-Adolf-Platz | 525 ft | 27 | skyscraper | 1921 | ||
| 2 | Twist 55 | 361 ft | 26 | skyscraper | 2025 | ||
| 3 | VICTORIA-Haus | 6 | 354 ft | 29 | skyscraper | 1998 | |
| 4 | Calatrava Hochhaus | 328 ft | - | skyscraper | 2027 | ||
| 5 | Dreischeibenhaus | 8 | 311 ft | 26 | high-rise building | 1960 | |
| 6 | Gateway | 302 ft | 24 | high-rise building | 2024 | ||
| 7 | GAP 15 | 8 | 295 ft | 24 | high-rise building | 2005 | |
| 8 | Mannesmann-Hochhaus | 10 | 290 ft | 25 | high-rise building | 1958 | |
| 9 | Johanneskirche | 2 | 286 ft | - | church | 1881 | |
| 10 | Sky Office | 11 | 285 ft | 23 | high-rise building | 2009 | |
| 11 | Landeszentralbank | 3 | 242 ft | 26 | high-rise building | 1987 | |
| 12 | Stadtsparkasse | 3 | 236 ft | 19 | high-rise building | 1964 | |
| 13 | Stiftskirche Sankt Lambertus | 1 | 230 ft | - | church | 1394 | |
| 14 | 25 Hours Hotel Düsseldorf | 4 | 213 ft | 19 | high-rise building | 2018 | |
| 15 | Pandion D'Or | 2 | 200 ft | 18 | high-rise building | 2015 | |
| 16 | Sternhaus | 200 ft | 17 | high-rise building | 1972 | ||
| 17 | Pandion Le Grand | 3 | 197 ft | 18 | high-rise building | 2017 | |
| 18 | Eclipse | 197 ft | 16 | high-rise building | 2022 | ||
| 19 | Horizon | 197 ft | 16 | high-rise building | 2017 | ||
| 20 | Kreuzkirche | 197 ft | - | church | 1910 |