Rochester was founded in 1854 along a bend in the Zumbro River, and named after the founder's hometown of Rochester , New York. Located approximately 75 miles southeast of Minneapolis - St. Paul , the seat of Olmsted County has grown into the third-largest city in Minnesota. Rochester is famous as home of the Mayo Clinic , one of the largest and most prestigious medical centers in the world. The hospital here is consistently rated the second best in the United States. The high-rises at the Mayo Clinic and the neighboring residential and hotel towers lend Rochester an impressive skyline for a city of fewer than 100,000.